Details of the Target

General Information of Target

Target ID LDTP14393
Target Name Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3)
Gene Name GABRR3
Gene ID 200959
Synonyms
Gamma-aminobutyric acid receptor subunit rho-3; GABA(A) receptor subunit rho-3; GABA(C) receptor
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
KEERDLVDRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLET
GPEAERLEQLESGEEELVLAEYESDEEKKVASGHRVDEDEDDLEEEHITKIYHCSRTHSQ
LAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQLINDRCVDMQRSRHEKKKG
AEEEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYRSRLA
IPAAKLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQA
HSQLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTI
NDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQ
PRTTEALAAPADESQASVPQPASPLMHIEGFLAALTTANQDGRVILSRQGSLSESTLKFL
LLNPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNI
PLVICSGISNQPLEFTFQKRDLPQMMDEVGRILCNLCGVVSGGVVCFFSSYEYLRQVHAH
WEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTEALLLSVVGGKM
SEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMK
AVNQSIGRAIRHQKDFASIVLLDQRYARPPVLAKLPAWIRASVEVKATFGPAIAAVQKFH
REKSASS
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRR3 sub-subfamily
Subcellular location
Postsynaptic cell membrane
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
TTD ID
T11858
Uniprot ID
A8MPY1
DrugMap ID
TT4N6D8
Ensemble ID
ENST00000472788.6
HGNC ID
HGNC:17969
ChEMBL ID
CHEMBL2109242

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(+/-)-cis-2-camp Small molecular drug D0WV8K
5-me-iaa Small molecular drug D0C7PZ
Aza-thip Small molecular drug D0OY1R
Cis-3-acpbpa Small molecular drug D0B0WU
Isonipecotic Acid Small molecular drug D0AC2H
Piperidine-4-sulphonic Acid Small molecular drug D0VW5M
Tbps Small molecular drug D0P0TI
Tpmpa Small molecular drug D0U4HM
Trans-3-acpbpa Small molecular drug D0A6RM
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fludiazepam Small molecular drug DB01567

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.