Details of the Target
General Information of Target
| Target ID | LDTP14364 | |||||
|---|---|---|---|---|---|---|
| Target Name | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (FBLL1) | |||||
| Gene Name | FBLL1 | |||||
| Synonyms |
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; EC 2.1.1.-; Protein-glutamine methyltransferase |
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| 3D Structure | ||||||
| Sequence |
MWMFSWLCAILIILAIAGMNTIAKTTPHTKFTKKSEEREMPKGLKPSSGPPPEEEETLFT
EMAEMAEPITKPSALDSVFGTATLSPFENFTLDPADFFLNCCDCCSPVPGQKGEPGETGQ PGPKGEAGNLGIPGPPGVVGPQGPRGYKGEKGLKGERGDQGVPGYPGKPGAQGEPGPKGD KGNIGLGGVKGQKGSKGDTCGNCTKGEKGDQGAMGSPGLHGGPGAKGEKGEMGEKGEMGD KGCCGDSGERGGKGQKGEGGMKGEKGSKGDSGMEGKSGRNGLPGAKGDPGIKGEKGELGP PGLLGPTGPKGDIGNKGVRGPTGKKGSRGFKGSKGELARVPRSAFSAGLSKPFPPPNIPI KFEKILYNDQGNYSPVTGKFNCSIPGTYVFSYHITVRGRPARISLVAQNKKQFKSRETLY GQEIDQASLLVILKLSAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPEETSGISP |
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| Target Bioclass |
Enzyme
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| Family |
Methyltransferase superfamily, Fibrillarin family
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| Subcellular location |
Nucleus, nucleolus
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| Function |
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
YN-1 Probe Info |
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100.00 | LDD0444 | [1] | |
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DBIA Probe Info |
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C280(1.85) | LDD3340 | [2] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STS-2 Probe Info |
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N.A. | LDD0138 | [3] | |
Competitor(s) Related to This Target
References