Details of the Target
General Information of Target
| Target ID | LDTP14362 | |||||
|---|---|---|---|---|---|---|
| Target Name | Calpain-8 (CAPN8) | |||||
| Gene Name | CAPN8 | |||||
| Gene ID | 388743 | |||||
| Synonyms |
NCL2; Calpain-8; EC 3.4.22.53; New calpain 2; nCL-2; Stomach-specific M-type calpain |
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| 3D Structure | ||||||
| Sequence |
MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFL
LSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDR YAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETP VLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCS SHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALT RCMGRCVALSRE |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase C2 family
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| Subcellular location |
Cytoplasm
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| Function |
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C82(1.56) | LDD3360 | [1] | |
|
Acrolein Probe Info |
 |
N.A. | LDD0221 | [2] | |
Competitor(s) Related to This Target
References