Details of the Target

General Information of Target

Target ID LDTP14341
Target Name EF-hand calcium-binding domain-containing protein 5 (EFCAB5)
Gene Name EFCAB5
Gene ID 374786
Synonyms
EF-hand calcium-binding domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY
LQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNF
VLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD
SQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMP
DKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTP
EKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLG
DEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAP
PPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSND
ERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQK
TRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLT
DIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY
Target Bioclass
Other
Uniprot ID
A4FU69
Ensemble ID
ENST00000394835.8
HGNC ID
HGNC:24801

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.K700RfsTer14 .
C32 SNV: p.P320S .
CFPAC1 SNV: p.I274V .
CMK SNV: p.A1011T .
HT115 SNV: p.K1286N .
KMCH1 SNV: p.H398N .
LS180 SNV: p.M1469V .
MCC13 SNV: p.E859K; p.E903K .
MEWO SNV: p.Y458N .
MFE319 Insertion: p.M767NfsTer7 .
MOLT4 Deletion: p.F843LfsTer13 .
NCIH661 SNV: p.S813Ter; p.A1243P .
RD SNV: p.V835I .
REH SNV: p.L1326F .
RT112 SNV: p.H1014R .
SUPT1 SNV: p.Q867Ter .
SW620 SNV: p.W434Ter .
TE4 SNV: p.L67Q .
TOV21G SNV: p.A1044T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N.A.  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.