Details of the Target

General Information of Target

Target ID LDTP14339
Target Name Myotubularin-related protein 11 (MTMR11)
Gene Name MTMR11
Gene ID 10903
Synonyms
Myotubularin-related protein 11; Cisplatin resistance-associated protein; hCRA; Inactive phosphatidylinositol 3-phosphatase 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHFSSSARAADENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLD
IDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGA
ANVVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLETSAKESKNIEEVFVLMAKELI
ARNSLHLYGESALNGLPLDSSPVLMAQGPSEKTHCTC
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Uniprot ID
A4FU01
Ensemble ID
ENST00000369140.7
HGNC ID
HGNC:24307

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C40(1.14)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 MCF-7 C40(2.52)  LDD2869  [1]
 LDCM0024  KB05 ZR-75-1 C40(1.14)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840