Details of the Target

General Information of Target

Target ID LDTP14334
Target Name Protein tyrosine phosphatase domain-containing protein 1 (PTPDC1)
Gene Name PTPDC1
Gene ID 138639
Synonyms
PTP9Q22; Protein tyrosine phosphatase domain-containing protein 1; EC 3.1.3.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEPDTSSGFSGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLI
IALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class PTPDC1 subfamily
Function May play roles in cilia formation and/or maintenance.
Uniprot ID
A2A3K4
Ensemble ID
ENST00000288976.3
HGNC ID
HGNC:30184

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C288(1.75)  LDD3419  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C236(1.13)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C236(1.17)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C236(1.08)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C236(1.20)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C236(1.40)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C236(1.04)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C236(1.28)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C236(1.16)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C236(1.07)  LDD1611  [4]
 LDCM0414  CL26 HEK-293T C236(0.98)  LDD1618  [4]
 LDCM0441  CL50 HEK-293T C236(1.20)  LDD1645  [4]
 LDCM0454  CL62 HEK-293T C236(1.13)  LDD1657  [4]
 LDCM0467  CL74 HEK-293T C236(1.05)  LDD1670  [4]
 LDCM0480  CL86 HEK-293T C236(1.02)  LDD1683  [4]
 LDCM0493  CL98 HEK-293T C236(1.37)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C236(1.12)  LDD1631  [4]
 LDCM0022  KB02 G-361 C288(2.21)  LDD2329  [1]
 LDCM0023  KB03 G-361 C288(2.98)  LDD2746  [1]
 LDCM0024  KB05 SH-4 C288(1.75)  LDD3419  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crk-like protein (CRKL) CRK family P46109

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402