Details of the Target

General Information of Target

Target ID LDTP14331
Target Name NADH dehydrogenase 1 alpha subcomplex assembly factor 8 (NDUFAF8)
Gene Name NDUFAF8
Gene ID 284184
Synonyms
C17orf89; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGE
DGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYK
EAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVT
GRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVG
PKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNN
ENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQG
GDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARA
GPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAA
LVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS
Target Bioclass
Other
Subcellular location
Mitochondrion
Function Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5.
Uniprot ID
A1L188
Ensemble ID
ENST00000431388.3
HGNC ID
HGNC:33551

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C35(0.00); C25(0.00); C61(0.00)  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264