Details of the Target

General Information of Target

Target ID LDTP14329
Target Name BICD family-like cargo adapter 2 (BICDL2)
Gene Name BICDL2
Gene ID 146439
Synonyms
BICDR2; CCDC64B; BICD family-like cargo adapter 2; Bicaudal D-related protein 2; BICD-related protein 2; BICDR-2; Coiled-coil domain-containing protein 64B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLQGQFKSLAFYLLFTGAAVSICEGAYF
VAQLLAICFQCQPGSLADRVREKAHWLGCFQKFLAYLLLSVACFLHPVLVWHVTIPGSML
IITGLAYFLLSKRKKRKAAPEVLASPEQYTDPSSSAVSTTGSGDTEQTYTFHGALKEGPS
SLFIHMKSILKGTKKPSALQPPNTLMELSLEPADSLAKKKQVHFEDNLVRIVPSLAEGLD
DGDSEPEETTSDTTPIIPPPQAPLFLSSLTATGLF
Target Bioclass
Other
Family
BICDR family
Uniprot ID
A1A5D9
Ensemble ID
ENST00000389347.4
HGNC ID
HGNC:33584

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A65E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C185(1.99)  LDD3439  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 EGI-1 C185(1.65)  LDD2323  [1]
 LDCM0023  KB03 ECC2 C185(1.54)  LDD2737  [1]
 LDCM0024  KB05 SNU-1196 C185(1.99)  LDD3439  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 17 (CDK17) CMGC Ser/Thr protein kinase family Q00537
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.