Details of the Target

General Information of Target

Target ID LDTP14327
Target Name Glucoside xylosyltransferase 2 (GXYLT2)
Gene Name GXYLT2
Gene ID 727936
Synonyms
GLT8D4; Glucoside xylosyltransferase 2; EC 2.4.2.42; Glycosyltransferase 8 domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQCLRYQMHWEDLEEYQALTFLTRNEILCIHDTFLKLCPPGKYYKEATLTMDQVSSLPA
LRVNPFRDRICRVFSHKGMFSFEDVLGMASVFSEQACPSLKIEYAFRIYDFNENGFIDEE
DLQRIILRLLNSDDMSEDLLMDLTNHVLSESDLDNDNMLSFSEFEHAMAKSPDFMNSFRI
HFWGC
Target Bioclass
Enzyme
Family
Glycosyltransferase 8 family
Subcellular location
Membrane
Function Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
Uniprot ID
A0PJZ3
Ensemble ID
ENST00000389617.9
HGNC ID
HGNC:33383

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853