Details of the Target
General Information of Target
| Target ID | LDTP14267 | |||||
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| Target Name | Adenylate kinase isoenzyme 5 (AK5) |
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| Gene Name | AK5 | |||||
| Gene ID | 26289 | |||||
| Synonyms |
Adenylate kinase isoenzyme 5; AK 5; EC 2.7.4.3; EC 2.7.4.6; ATP-AMP transphosphorylase 5 |
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| 3D Structure | ||||||
| Sequence |
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG
GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL NCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP WPVKAAV |
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| Target Bioclass |
Enzyme
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| Family |
Adenylate kinase family
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| Subcellular location |
Cytoplasm
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| Function |
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
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| A431 | SNV: p.S229C | . | |||
| AN3CA | SNV: p.I106M; p.A116V | . | |||
| HCC15 | Substitution: p.L415P | . | |||
| HCT15 | SNV: p.K203R | DBIA Probe Info | |||
| HT3 | SNV: p.E252Q | . | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.G262C | . | |||
| MDAMB453 | SNV: p.L150F | . | |||
| MEWO | SNV: p.S105F | . | |||
| NCIH1792 | SNV: p.A225G | DBIA Probe Info | |||
| NCIH2286 | SNV: p.M1? | . | |||
| NCIH23 | SNV: p.R253K | . | |||
| RKN | SNV: p.T58A | DBIA Probe Info | |||
| SUIT2 | SNV: p.D509N | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C627(1.39) | LDD3311 | [1] | |
Competitor(s) Related to This Target