Details of the Target

General Information of Target

Target ID LDTP14247
Target Name Transmembrane protein 14A (TMEM14A)
Gene Name TMEM14A
Gene ID 28978
Synonyms
C6orf73; Transmembrane protein 14A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPPLPSRLGLLLLLLLCPAHVGGLWWAVGSPLVMDPTSICRKARRLAGRQAELCQAEPE
VVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRILQQDIRETAFVFAITAAGASHAV
TQACSMGELLQCGCQAPRGRAPPRPSGLPGTPGPPGPAGSPEGSAAWEWGGCGDDVDFGD
EKSRLFMDARHKRGRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKL
PPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLKPPGRADLLYAADSPDFCAPNRRT
GSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKE
LSLCL
Target Bioclass
Transporter and channel
Family
TMEM14 family
Subcellular location
Mitochondrion membrane
Function Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
Uniprot ID
Q9Y6G1
Ensemble ID
ENST00000211314.5
HGNC ID
HGNC:21076

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C37(0.94)  LDD1508  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C37(0.94)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C37(0.89)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C37(1.06)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C37(1.00)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C37(0.89)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C37(0.77)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C37(0.78)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C37(0.84)  LDD1560  [1]
 LDCM0405  CL18 HEK-293T C37(0.88)  LDD1609  [1]
 LDCM0419  CL30 HEK-293T C37(0.90)  LDD1623  [1]
 LDCM0432  CL42 HEK-293T C37(1.03)  LDD1636  [1]
 LDCM0445  CL54 HEK-293T C37(1.01)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C37(1.10)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C37(0.80)  LDD1661  [1]
 LDCM0471  CL78 HEK-293T C37(0.90)  LDD1674  [1]
 LDCM0485  CL90 HEK-293T C37(0.89)  LDD1688  [1]
 LDCM0022  KB02 LN-18 C37(1.29)  LDD2440  [3]
 LDCM0023  KB03 LN-18 C37(2.22)  LDD2857  [3]
 LDCM0024  KB05 LN-18 C37(1.88)  LDD3274  [3]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840