Details of the Target
General Information of Target
| Target ID | LDTP14197 | |||||
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| Target Name | Interleukin-1 receptor-associated kinase 3 (IRAK3) |
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| Gene Name | IRAK3 | |||||
| Gene ID | 11213 | |||||
| Synonyms |
Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M; Inactive IL-1 receptor-associated kinase 3 |
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| 3D Structure | ||||||
| Sequence |
MWAPPAAIMGDGPTKKVGNQAPLQTQALQTASLRDGPAKRAVWVRHTSSEPQEPTESKAA
KERPKQEVTKAVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGDNRKETFVGQ ELNNTNVHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNR EKYAEMLFEAFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITG RLDYAGSDLTAYLLGLLNSAGNEFTQDQMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIR YVLPDGKEIQLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILL CGGSTMLSGFPNRLQKELSSMCPNDTPQVNVLPERDSAVWTGGSILASLQGFQPLWVHRF EYEEHGPFFLYRRCF |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
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| Subcellular location |
Cytoplasm
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| Function |
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
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Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
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| A431 | SNV: p.K594E | . | |||
| HEL | SNV: p.E494K | DBIA Probe Info | |||
| HEL9217 | SNV: p.E494K | DBIA Probe Info | |||
| OVK18 | Deletion: p.M200CfsTer26 | DBIA Probe Info | |||
| RKO | Insertion: p.N223KfsTer13 SNV: p.S333N |
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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IPM Probe Info |
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N.A. | LDD0241 | [1] | |
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DBIA Probe Info |
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C581(1.17); C572(1.04); C532(0.87); C539(0.87) | LDD0078 | [2] | |
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W1 Probe Info |
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N.A. | LDD0236 | [1] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References