Details of the Target

General Information of Target

Target ID LDTP14187
Target Name Beta-1,3-galactosyltransferase 1 (B3GALT1)
Gene Name B3GALT1
Gene ID 8708
Synonyms
Beta-1,3-galactosyltransferase 1; Beta-1,3-GalTase 1; Beta3Gal-T1; Beta3GalT1; EC 2.4.1.86; UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDS
AIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPP
RPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYN
SPVKLLNRNNEVWLIQKNEPTKENE
Target Bioclass
Enzyme
Family
Glycosyltransferase 31 family
Subcellular location
Golgi apparatus membrane
Function
Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
Uniprot ID
Q9Y5Z6
Ensemble ID
ENST00000392690.4
HGNC ID
HGNC:916
ChEMBL ID
CHEMBL2321634

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C167(1.22)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C167(1.22)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C167(1.11)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C167(1.28)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C167(1.10)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C167(1.15)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C167(1.10)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C167(1.45)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C167(0.99)  LDD1570  [1]
 LDCM0404  CL17 HEK-293T C167(1.24)  LDD1608  [1]
 LDCM0417  CL29 HEK-293T C167(1.38)  LDD1621  [1]
 LDCM0431  CL41 HEK-293T C167(1.14)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C167(1.22)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C167(0.99)  LDD1647  [1]
 LDCM0457  CL65 HEK-293T C167(1.23)  LDD1660  [1]
 LDCM0470  CL77 HEK-293T C167(1.37)  LDD1673  [1]
 LDCM0483  CL89 HEK-293T C167(0.93)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402