Details of the Target
General Information of Target
| Target ID | LDTP14177 | |||||
|---|---|---|---|---|---|---|
| Target Name | Endothelial lipase (LIPG) | |||||
| Gene Name | LIPG | |||||
| Gene ID | 9388 | |||||
| Synonyms |
Endothelial lipase; EC 3.1.1.3; Endothelial cell-derived lipase; EDL; EL; Phospholipase A1; EC 3.1.1.32 |
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| 3D Structure | ||||||
| Sequence |
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRR
LGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWN VNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHT VTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVA IAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQN KTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKN QEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFA HWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQ LVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI |
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| Target Type |
Clinical trial
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| Target Bioclass |
Enzyme
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| Family |
AB hydrolase superfamily, Lipase family
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| Subcellular location |
Secreted
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| Function |
Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins.
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| TTD ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C316(2.48) | LDD3493 | [1] | |
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NAIA_4 Probe Info |
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N.A. | LDD2226 | [2] | |
Competitor(s) Related to This Target
References