Details of the Target

General Information of Target

Target ID	LDTP14167
Target Name	Wnt inhibitory factor 1 (WIF1)
Gene Name	WIF1
Gene ID	11197
Synonyms	Wnt inhibitory factor 1; WIF-1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MALSEPILPSFSTFASPCRERGLQERWPRAEPESGGTDDDLNSVLDFILSMGLDGLGAEA APEPPPPPPPPAFYYPEPGAPPPYSAPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRL VKAEPPEADGGGGYGCAPGLTRGPRGLKREGAPGPAASCMRGPGGRPPPPPDTPPLSPDG PARLPAPGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGLAPPAAR GLLTPPASPLELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEK PYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM
Target Bioclass	Other
Subcellular location	Secreted
Function	Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
Uniprot ID	Q9Y5W5
Ensemble ID	ENST00000286574.9
HGNC ID	HGNC:18081

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IPM Probe Info			N.A.	LDD0005	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 4 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1)	CYSRT1 family	A8MQ03
Keratin-associated protein 10-8 (KRTAP10-8)	KRTAP type 10 family	P60410
Protein Wnt-5a (WNT5A)	Wnt family	P41221
Protein Wnt-7a (WNT7A)	Wnt family	O00755

References

1	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764