Details of the Target

General Information of Target

Target ID LDTP14151
Target Name Doublesex- and mab-3-related transcription factor 2 (DMRT2)
Gene Name DMRT2
Gene ID 10655
Synonyms
DSXL2; Doublesex- and mab-3-related transcription factor 2; Doublesex-like 2 protein; DSXL-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEA
RESSEYIVAHVLGAKTFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQ
GLSLRMVPPVFIPRPETEELVEWVLEEVAQRSHAVGSPGSPLILEVGCGSGAISLSLLSQ
LPQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNP
PYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHP
ELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP
Target Bioclass
Transcription factor
Family
DMRT family
Subcellular location
Nucleus
Function
Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome.
Uniprot ID
Q9Y5R5
Ensemble ID
ENST00000259622.10
HGNC ID
HGNC:2935

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.P470S .
CORL23 SNV: p.E217Ter .
HEC1B SNV: p.A555V .
IM95 SNV: p.S181F .
NCIH2172 SNV: p.S338Y .
NCIH358 SNV: p.H138Q .
RKO SNV: p.D48G .
WM2664 Insertion: p.M249YfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C105(1.83)  LDD3410  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-375 C105(1.66)  LDD2255  [1]
 LDCM0023  KB03 A101D C105(1.79)  LDD2667  [1]
 LDCM0024  KB05 RPMI-7951 C105(1.83)  LDD3410  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840