Details of the Target
General Information of Target
| Target ID | LDTP14150 | |||||
|---|---|---|---|---|---|---|
| Target Name | MTRF1L release factor glutamine methyltransferase (HEMK1) | |||||
| Gene Name | HEMK1 | |||||
| Gene ID | 51409 | |||||
| Synonyms |
HEMK; MTRF1L release factor glutamine methyltransferase; EC 2.1.1.297; HemK methyltransferase family member 1; M.HsaHemKP |
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| 3D Structure | ||||||
| Sequence |
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV |
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| Target Bioclass |
Enzyme
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| Family |
Protein N5-glutamine methyltransferase family
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| Subcellular location |
Mitochondrion
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| Function |
N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factors MTRF1, MTRF1L, MRPL58/ICT1 and MTRFR.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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Compound 10 Probe Info |
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N.A. | LDD2216 | [1] | |