Details of the Target

General Information of Target

Target ID LDTP14129
Target Name Choline-phosphate cytidylyltransferase B (PCYT1B)
Gene Name PCYT1B
Gene ID 9468
Synonyms
CCTB; Choline-phosphate cytidylyltransferase B; EC 2.7.7.15; CCT-beta; CTP:phosphocholine cytidylyltransferase B; CCT B; CT B; Phosphorylcholine transferase B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVL
VHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLI
KLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSK
LYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNL
CKFTEWIEKTVQAS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cytidylyltransferase family
Subcellular location
Cytoplasm; Endoplasmic reticulum
Function
[Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.; [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
TTD ID
T95998
Uniprot ID
Q9Y5K3
DrugMap ID
TTUAIKM
Ensemble ID
ENST00000356768.8
HGNC ID
HGNC:8755

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R211C .
JURKAT SNV: p.E131D .
NCIH1793 SNV: p.N288Y .
OVTOKO SNV: p.F88L .
SNGM SNV: p.M361I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y173(0.91)  LDD0264  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y173(0.91)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y173(0.55)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y173(12.81)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y173(0.40)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y173(1.50)  LDD0268  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) VKOR family Q8N0U8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Small molecular drug DB00122
Choline Salicylate Small molecular drug DB14006
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ct-2584 Small molecular drug D0V0DI
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sphingosine Small molecular drug D0L0YG
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholesterol Small molecular drug D02DLW

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.