Details of the Target
General Information of Target
| Target ID | LDTP14114 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protocadherin beta-11 (PCDHB11) | |||||
| Gene Name | PCDHB11 | |||||
| Gene ID | 56125 | |||||
| Synonyms |
Protocadherin beta-11; PCDH-beta-11 |
|||||
| 3D Structure | ||||||
| Sequence |
MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELS
SRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIE LQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHV KIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSP EFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGD ITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENT PETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNIT ITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDS GTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPA LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNA WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA PVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTG SEVEENPPFQNNLGF |
|||||
| Target Bioclass |
Other
|
|||||
| Subcellular location |
Cell membrane
|
|||||
| Function | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A375 | SNV: p.D509N | DBIA Probe Info | |||
| CAL51 | SNV: p.N463S | DBIA Probe Info | |||
| CCK81 | SNV: p.R712Q | . | |||
| DU145 | SNV: p.D374Y | DBIA Probe Info | |||
| ETK1 | SNV: p.D377V | . | |||
| HCT116 | SNV: p.T280I | . | |||
| HCT15 | SNV: p.A157V | . | |||
| HEC1 | SNV: p.A719V | DBIA Probe Info | |||
| HEC1B | SNV: p.A719V | . | |||
| HT115 | SNV: p.E58Ter; p.A64V; p.G379E | . | |||
| HUPT4 | Deletion: p.G325EfsTer10 | . | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.L658V | DBIA Probe Info | |||
| KYSE30 | SNV: p.P186S | . | |||
| LS180 | SNV: p.R712Q | DBIA Probe Info | |||
| MEWO | SNV: p.G224E | . | |||
| NCIH1793 | SNV: p.A526S; p.D593E | . | |||
| NCIH2170 | SNV: p.A199E | . | |||
| NCIH3122 | SNV: p.A415V | DBIA Probe Info | |||
| OSRC2 | SNV: p.P582S | . | |||
| RKO | Substitution: p.E204L | . | |||
| SNU423 | SNV: p.D446N | . | |||
| SUPT1 | SNV: p.R652H | . | |||
| SW756 | SNV: p.E398D | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C383(1.45) | LDD3312 | [1] | |
Competitor(s) Related to This Target