Details of the Target

General Information of Target

Target ID LDTP14001
Target Name N-acetylated-alpha-linked acidic dipeptidase 2 (NAALAD2)
Gene Name NAALAD2
Gene ID 10003
Synonyms
N-acetylated-alpha-linked acidic dipeptidase 2; EC 3.4.17.21; Glutamate carboxypeptidase III; GCPIII; N-acetylated-alpha-linked acidic dipeptidase II; NAALADase II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL
QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS
LPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQI
SLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNA
ELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKE
DDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVRNS
DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE
PVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESE
SERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILET
WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKES
PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLL
HMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEA
HMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGAL
KFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFER
ENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEE
EKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIE
KIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQ
LVEAECKIQDLEHHLGLALNEVQAAKKTWFNRTLSSIKTATGVQGKETC
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M28 family, M28B subfamily
Subcellular location
Cell membrane
Function Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.
TTD ID
T70036
Uniprot ID
Q9Y3Q0
DrugMap ID
TTUWQLT
Ensemble ID
ENST00000375944.7
HGNC ID
HGNC:14526
ChEMBL ID
CHEMBL2609

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A222V .
CCSW1 SNV: p.V315M .
DU145 SNV: p.I319T; p.G320V .
HCT15 SNV: p.G325V .
HSC4 SNV: p.L660R .
IGROV1 SNV: p.P283S .
J82 SNV: p.G188V .
MDAMB436 SNV: p.I294L .
NCIH1793 SNV: p.E77V .
NCIH1975 SNV: p.P233H .
NCIH2172 SNV: p.L178Q .
NCIH358 SNV: p.R171L .
P31FUJ SNV: p.Y103C .
SNGM SNV: p.N647S .
SNU869 SNV: p.S486G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K562(5.56)  LDD0274  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270