Details of the Target

General Information of Target

Target ID LDTP13998
Target Name Zinc finger protein 337 (ZNF337)
Gene Name ZNF337
Gene ID 26152
Synonyms
Zinc finger protein 337
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEA
KEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK
LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMRNT
TSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRDVL
NHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESFKA
MQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKCHEANKRG
GMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDS
SNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEKD
DLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEGNS
VSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAP
ASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAV
FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPEN
VNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLAD
ENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATG
KPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLE
ESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVE
APPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKT
DLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPE
WYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9Y3M9
Ensemble ID
ENST00000252979.6
HGNC ID
HGNC:15809

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.R635Q .
HEC1 SNV: p.P487S; p.S670R .
HEC1B SNV: p.P487S .
IGR1 SNV: p.P403L .
Ishikawa (Heraklio) 02 ER SNV: p.R284K .
KMCH1 Insertion: p.A201SfsTer18 .
LNCaP clone FGC SNV: p.S133Y .
MCC13 SNV: p.P319L .
MFE319 SNV: p.S306P .
NCIH2172 SNV: p.T565A .
NOMO1 SNV: p.I364T .
OV56 Deletion: p.H370QfsTer17 .
SKOV3 SNV: p.Y273H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C82(4.29)  LDD3430  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
W1
 Probe Info  		N.A.  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C82(2.15)  LDD2250  [1]
 LDCM0023  KB03 COLO-800 C82(4.03)  LDD2724  [1]
 LDCM0024  KB05 SK-MEL-5 C82(4.29)  LDD3430  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycine N-methyltransferase (GNMT) Glycine N-methyltransferase family Q14749
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.