Details of the Target

General Information of Target

Target ID LDTP13962
Target Name Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4)
Gene Name COQ4
Gene ID 51117
Synonyms
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Coenzyme Q biosynthesis protein 4 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSSAALPRILGAGARAPSRWLGFLGKATPRPARPSRRTLGSATALMIRESEDSTDFND
KILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIFGSRLDHDIIDLEQ
TATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIENMARDCGEYAHTRYFRGGMLTNAR
LLFGPTVRLPDLIIFLHTLNNIFEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGND
DSPLAVHLYCRLFQTAITRAKEKRQQVEALYRLQGQKEPGDQGPAHPPGADMSHSL
Target Bioclass
Other
Family
COQ4 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. {|HAMAP-Rule:MF_03111}.
Uniprot ID
Q9Y3A0
Ensemble ID
ENST00000300452.8
HGNC ID
HGNC:19693

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.S56F .
MOLT4 SNV: p.L85P .
TOV21G SNV: p.E161Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) MenG/UbiE family Q5HYK3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) UbiG/COQ3 family Q9NZJ6
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) COQ7 family Q99807
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) UbiH/COQ6 family Q9Y2Z9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019