Details of the Target

General Information of Target

Target ID LDTP13931
Target Name Zinc finger and BTB domain-containing protein 32 (ZBTB32)
Gene Name ZBTB32
Gene ID 27033
Synonyms
FAZF; TZFP; ZNF538; Zinc finger and BTB domain-containing protein 32; FANCC-interacting protein; Fanconi anemia zinc finger protein; Testis zinc finger protein; Zinc finger protein 538
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells.
Uniprot ID
Q9Y2Y4
Ensemble ID
ENST00000262630.7
HGNC ID
HGNC:16763

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C356(1.67)  LDD2355  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HG-3 C356(1.67)  LDD2355  [1]
 LDCM0023  KB03 HG-3 C356(1.88)  LDD2772  [1]
 LDCM0024  KB05 HG-3 C356(1.88)  LDD3189  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.