Details of the Target

General Information of Target

Target ID LDTP13861
Target Name Phospholipid-transporting ATPase IF (ATP11B)
Gene Name ATP11B
Gene ID 23200
Synonyms
ATPIF; ATPIR; KIAA0956; Phospholipid-transporting ATPase IF; EC 7.6.2.1; ATPase IR; ATPase class VI type 11B; P4-ATPase flippase complex alpha subunit ATP11B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFF
QAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSE
EQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRY
SVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAE
PEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMG
ILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQ
TSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITE
KRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEV
LTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Subcellular location
Recycling endosome membrane
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes. May contribute to the maintenance of membrane lipid asymmetry in endosome compartment.
Uniprot ID
Q9Y2G3
Ensemble ID
ENST00000323116.10
HGNC ID
HGNC:13553

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C422(1.80)  LDD3310  [2]
IA-alkyne
 Probe Info  		C787(0.00); C792(0.00); C793(0.00)  LDD2241  [3]
Lodoacetamide azide
 Probe Info  		C787(0.00); C792(0.00); C793(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C741(0.84)  LDD1576  [5]
 LDCM0376  CL107 HEK-293T C741(0.92)  LDD1580  [5]
 LDCM0381  CL111 HEK-293T C741(0.88)  LDD1585  [5]
 LDCM0385  CL115 HEK-293T C741(0.91)  LDD1589  [5]
 LDCM0389  CL119 HEK-293T C741(0.87)  LDD1593  [5]
 LDCM0394  CL123 HEK-293T C741(1.18)  LDD1598  [5]
 LDCM0398  CL127 HEK-293T C741(0.95)  LDD1602  [5]
 LDCM0402  CL15 HEK-293T C741(1.11)  LDD1606  [5]
 LDCM0415  CL27 HEK-293T C741(0.82)  LDD1619  [5]
 LDCM0418  CL3 HEK-293T C741(0.92)  LDD1622  [5]
 LDCM0428  CL39 HEK-293T C741(0.95)  LDD1632  [5]
 LDCM0455  CL63 HEK-293T C741(0.92)  LDD1658  [5]
 LDCM0481  CL87 HEK-293T C741(1.04)  LDD1684  [5]
 LDCM0494  CL99 HEK-293T C741(0.83)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C741(1.22)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C741(0.94)  LDD1671  [5]
 LDCM0022  KB02 DEL C422(1.72)  LDD2315  [2]
 LDCM0023  KB03 DEL C422(1.84)  LDD2732  [2]
 LDCM0024  KB05 COLO792 C422(1.80)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell cycle control protein 50A (TMEM30A) CDC50/LEM3 family Q9NV96

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402