Details of the Target

General Information of Target

Target ID LDTP13859
Target Name Myelin regulatory factor (MYRF)
Gene Name MYRF
Gene ID 745
Synonyms
C11orf9; KIAA0954; MRF; Myelin regulatory factor; EC 3.4.-.-; Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKTNMEKLTFYALSAPEKLDRIGAYLSER
LIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTN
SFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVN
DELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKEKESPAELAERCLRELL
GRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDA
NSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVS
LGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSKVPRPSLHQAVDTGRTG
ENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILIS
FIDRHGNRHKFSTISTLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQ
KHYEALYGLLALISIELANEEVVVDLIRLVLAVQDVAQVNEENLPVYNRCALYALGAAYL
NLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKI
SEVLGGSGYNSDRLCLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEERVPAEE
ITYETLKKAIVDSVAVEEQERERRRQVVEKFQKAPFEEIAAHCGARASLLQSKLNQIFEI
TIRPPPSPSGTITAAYGQPQNHSIPVYEMKFPDLCVY
Target Bioclass
Enzyme
Family
MRF family
Subcellular location
Nucleus; Endoplasmic reticulum membrane
Function
[Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.; [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.; [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype.
Uniprot ID
Q9Y2G1
Ensemble ID
ENST00000265460.9
HGNC ID
HGNC:1181

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N893T .
CALU6 SNV: p.D391N .
COLO320 SNV: p.W353C .
EFO21 SNV: p.A292T .
EFO27 SNV: p.A217T .
HCT15 SNV: p.H480N .
IM95 Deletion: p.S264AfsTer8 .
JHH7 SNV: p.G822E .
JM1 SNV: p.K491N .
KMCH1 SNV: p.A927T .
KYSE180 SNV: p.P188L .
MEWO SNV: p.G994A .
MFE319 SNV: p.T601I .
MKN1 SNV: p.V806M .
NCIH1993 SNV: p.N347H .
NCIH23 Deletion: p.K112SfsTer41 .
NUGC3 Deletion: p.S264AfsTer8 .
OSRC2 SNV: p.V806M .
OVCAR8 SNV: p.G728V .
RKO SNV: p.H244R .
RL952 SNV: p.S861N .
SKMEL3 SNV: p.P115Q .
SNU1 Deletion: p.S264AfsTer8 .
SW837 SNV: p.R742M .
TE4 SNV: p.D713N .
TGBC1TKB SNV: p.S138F .
TOV21G SNV: p.P738H; p.P744T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C167(2.48)  LDD3444  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC108 C428(1.62)  LDD2381  [1]
 LDCM0023  KB03 HuH-28 C167(2.05)  LDD2792  [1]
 LDCM0024  KB05 SNU-478 C167(2.48)  LDD3444  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840