Details of the Target

General Information of Target

Target ID LDTP13821
Target Name Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)
Gene Name ST3GAL6
Gene ID 10402
Synonyms
SIAT10; Type 2 lactosamine alpha-2,3-sialyltransferase; EC 2.4.99.-; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDF
HRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLRQQ
ILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREIEQLVGDDPQRCAYFEISAKK
NSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGGDPG
DAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKERCVIS
Target Bioclass
Enzyme
Family
Glycosyltransferase 29 family
Subcellular location
Golgi apparatus membrane
Function
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.
Uniprot ID
Q9Y274
Ensemble ID
ENST00000265261.11
HGNC ID
HGNC:18080

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.V13A .
RKO Deletion: p.N323TfsTer3 .
RL952 Deletion: p.N323TfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C118(2.74)  LDD3428  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 G-361 C118(2.48)  LDD2329  [1]
 LDCM0023  KB03 G-361 C118(4.41)  LDD2746  [1]
 LDCM0024  KB05 SK-MEL3 C118(2.74)  LDD3428  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840