Details of the Target

General Information of Target

Target ID LDTP13811
Target Name Choline/ethanolamine kinase (CHKB)
Gene Name CHKB
Gene ID 1120
Synonyms
CHETK; CHKL; Choline/ethanolamine kinase; Choline kinase beta; CK; CKB; EC 2.7.1.32; Choline kinase-like protein; Ethanolamine kinase; EK; EC 2.7.1.82; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMGLSLASAVLLASLLSLHLGTATRGSDISKTCCFQYSHKPLPWTWVRSYEFTSNSCSQR
AVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL
Target Bioclass
Enzyme
Family
Choline/ethanolamine kinase family
Function Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
Uniprot ID
Q9Y259
Ensemble ID
ENST00000406938.3
HGNC ID
HGNC:1938
ChEMBL ID
CHEMBL3112385

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DAOY SNV: p.R377P .
HCT15 SNV: p.A374V .
HT Deletion: p.P204QfsTer7 .
IGR37 SNV: p.L153F .
IGR39 SNV: p.L153F .
Ishikawa (Heraklio) 02 ER Deletion: p.V237del .
KYSE150 SNV: p.E141D .
MOLT4 SNV: p.N247S .
SKNSH SNV: p.P29L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(1.67)  LDD3360  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C17(2.57)  LDD2227  [2]
 LDCM0022  KB02 BRX211 C28(1.75)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C28(2.94)  LDD2685  [1]
 LDCM0024  KB05 NCI-H3122 C28(1.67)  LDD3360  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264