Details of the Target

General Information of Target

Target ID LDTP13810
Target Name C-C motif chemokine 26 (CCL26)
Gene Name CCL26
Gene ID 10344
Synonyms
SCYA26; C-C motif chemokine 26; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALD
AFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGK
AFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVV
VTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTV
YLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQL
SASSHTDYASIPR
Target Bioclass
Cytokine and receptor
Family
Intercrine beta (chemokine CC) family
Subcellular location
Secreted
Function
Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis.
Uniprot ID
Q9Y258
Ensemble ID
ENST00000005180.9
HGNC ID
HGNC:10625

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C57(3.47); C73(4.12)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 OV-90 C57(2.48); C73(2.81)  LDD2546  [1]
 LDCM0023  KB03 OV-90 C57(3.41); C73(3.91)  LDD2963  [1]
 LDCM0024  KB05 OV-90 C57(3.47); C73(4.12)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840