Details of the Target

General Information of Target

Target ID LDTP13794
Target Name Deleted in lung and esophageal cancer protein 1 (DLEC1)
Gene Name DLEC1
Gene ID 9940
Synonyms
DLC1; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKS
GMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKF
GYHIIMVEGRK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Essential for spermatogenesis and male fertility. May play an important role in sperm head and tail formation. May act as a tumor suppressor by inhibiting cell proliferation.
Uniprot ID
Q9Y238
Ensemble ID
ENST00000308059.11
HGNC ID
HGNC:2899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L69P .
COLO678 Substitution: p.D147G .
COLO792 SNV: p.G686E .
CORL88 SNV: p.G492R .
FTC133 SNV: p.S1249P .
HT115 SNV: p.S343P; p.D484N .
IM95 Deletion: p.G427VfsTer8 .
Ishikawa (Heraklio) 02 ER Deletion: p.P334LfsTer21
SNV: p.L933V		 .
LN18 SNV: p.M1430I .
LNCaP clone FGC SNV: p.A165T; p.Q833H .
LUDLU1 SNV: p.Q1192Ter .
MELJUSO SNV: p.D1085N .
MEWO SNV: p.S701F .
NCIH1650 SNV: p.S412P .
OVK18 Deletion: p.V687FfsTer2 .
SNGM SNV: p.R1444W .
SNU308 Deletion: p.W41_S44del .
SW756 SNV: p.E18Q .
SW948 SNV: p.E676D .
TOV21G Deletion: p.P334LfsTer21 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K292(8.33)  LDD0274  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
W1
 Probe Info  		N.A.  LDD0236  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.