Details of the Target

General Information of Target

Target ID LDTP13776
Target Name Myotubularin-related protein 7 (MTMR7)
Gene Name MTMR7
Gene ID 9108
Synonyms
Myotubularin-related protein 7; Inositol 1,3-bisphosphate phosphatase; EC 3.1.3.-; Phosphatidylinositol-3-phosphate phosphatase; EC 3.1.3.64
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPP
LFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKG
EKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPG
SRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQG
QKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVN
NPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLT
PFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGS
DFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Subcellular location
Cytoplasm
Function Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).
Uniprot ID
Q9Y216
Ensemble ID
ENST00000180173.10
HGNC ID
HGNC:7454

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.A655V .
COLO678 SNV: p.P7L; p.K547N .
HT115 SNV: p.E411K; p.Y497H .
MCC26 SNV: p.E543K .
SHP77 Substitution: p.R344K .
SKMM2 SNV: p.N198D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myotubularin-related protein 9 (MTMR9) Protein-tyrosine phosphatase family Q96QG7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-H (CCNH) Cyclin family P51946

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.