Details of the Target

General Information of Target

Target ID LDTP13767
Target Name Tenascin-N (TNN)
Gene Name TNN
Gene ID 63923
Synonyms
TNW; Tenascin-N; TN-N; Tenascin-W; TN-W
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV
LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK
TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK
APSAARSLPSASTSKATISDEEIERQLKALGVD
Target Bioclass
Other
Family
Tenascin family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells.
Uniprot ID
Q9UQP3
Ensemble ID
ENST00000239462.9
HGNC ID
HGNC:22942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1237(1.31)  LDD3430  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C1237(3.50)  LDD2250  [1]
 LDCM0023  KB03 A101D C1237(3.50)  LDD2667  [1]
 LDCM0024  KB05 SK-MEL-5 C1237(1.31)  LDD3430  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840