Details of the Target

General Information of Target

Target ID LDTP13765
Target Name Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
Gene Name CAMK2A
Gene ID 815
Synonyms
CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; EC 2.7.11.17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELR
GALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
QEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIAS
TEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL
PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEI
TGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQ
FSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMST
SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATS
MRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGE
LPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEED
CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQ
SSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQE
TGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLP
CGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAM
GFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNF
FPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVS
AGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVS
ALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGET
EEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Subcellular location
Synapse
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.
Uniprot ID
Q9UQM7
Ensemble ID
ENST00000348628.11
HGNC ID
HGNC:1460
ChEMBL ID
CHEMBL4147

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, alpha skeletal muscle (ACTA1) Actin family P68133
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) Cation transport ATPase (P-type) (TC 3.A.3) family P13637
Valine--tRNA ligase (VARS1) Class-I aminoacyl-tRNA synthetase family P26640
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Beta-galactosidase-1-like protein 2 (GLB1L2) Glycosyl hydrolase 35 family Q8IW92
Hyaluronidase-3 (HYAL3) Glycosyl hydrolase 56 family O43820
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Phospholipid phosphatase 1 (PLPP1) PA-phosphatase related phosphoesterase family O14494
Purine nucleoside phosphorylase (PNP) PNP/MTAP phosphorylase family P00491
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) CAMK Ser/Thr protein kinase family Q13554
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Ras-related protein Rab-5A (RAB5A) Rab family P20339
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Glutamate receptor ionotropic, NMDA 2B (GRIN2B) Glutamate-gated ion channel family Q13224
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Protein S100-B (S100B) S-100 family P04271
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 19-3 (KRTAP19-3) KRTAP type 19 family Q7Z4W3
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
RNA-binding protein 47 (RBM47) RRM RBM47 family A0AV96
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8
Large ribosomal subunit protein uL11m (MRPL11) Universal ribosomal protein uL11 family Q9Y3B7
U3 small nucleolar RNA-associated protein 14 homolog A (UTP14A) UTP14 family Q9BVJ6
DAZ-associated protein 2 (DAZAP2) . Q15038
Keratin-associated protein 23-1 (KRTAP23-1) . A1A580
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Protein SPMIP9 (SPMIP9) . Q96LM6
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Tetratricopeptide repeat protein 5 (TTC5) . Q8N0Z6
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) . Q9NYJ8
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
14-dithiothreitol Small molecular drug DB04447
(2z3e)-23'-biindole-2'3(1h1'h)-dione 3-{O-[(3r)-34-dihydroxybutyl]Oxime} . DB07766
Hexatantalum Dodecabromide . DB04119

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.