Details of the Target

General Information of Target

Target ID LDTP13754
Target Name Catenin delta-2 (CTNND2)
Gene Name CTNND2
Gene ID 1501
Synonyms
NPRAP; Catenin delta-2; Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL
QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA
PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV
QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR
IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG
KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK
AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT
MSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLP
TLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSV
HTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRT
NAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYS
MVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQD
NLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEE
TQQPPLGGEEPTWPK
Target Bioclass
Other
Family
Beta-catenin family
Subcellular location
Nucleus
Function
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Uniprot ID
Q9UQB3
Ensemble ID
ENST00000304623.13
HGNC ID
HGNC:2516

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.K309N .
A549 SNV: p.P1181A .
CCK81 SNV: p.M1113T .
COLO679 SNV: p.E1209K .
EFO21 Substitution: p.L379P .
HCT15 SNV: p.P185L; p.K801R .
HEC1 SNV: p.Q507R DBIA    Probe Info 
HEC1B SNV: p.Q430Ter; p.Q507R .
HT115 SNV: p.S360L .
HT1197 SNV: p.K926E .
JHH7 SNV: p.R590I .
JURKAT SNV: p.D983N .
KARPAS422 SNV: p.S94R .
KMCH1 SNV: p.M975K .
KYSE150 SNV: p.G726E .
MEWO SNV: p.V76L; p.E122K; p.V124M; p.S1060F .
MFE319 SNV: p.E59G .
NCIH2172 SNV: p.M840I .
NCIH2286 SNV: p.L601M .
NCIH661 SNV: p.A368E .
REH SNV: p.P328L .
RH41 SNV: p.Y1019H .
RKO SNV: p.Y356C .
SCC25 SNV: p.G394S .
SKMEL3 SNV: p.G1119E .
SW1116 SNV: p.Q74L .
SW1271 SNV: p.V898L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1092(2.82)  LDD3332  [1]
NAIA_5
 Probe Info  		C1092(0.00); C509(0.00)  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C910(1.29)  LDD2254  [1]
 LDCM0023  KB03 A2780 C910(1.47)  LDD2671  [1]
 LDCM0024  KB05 MKN45 C1092(2.82)  LDD3332  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264