Details of the Target
General Information of Target
| Target ID | LDTP13741 | |||||
|---|---|---|---|---|---|---|
| Target Name | Potassium voltage-gated channel subfamily H member 4 (KCNH4) | |||||
| Gene Name | KCNH4 | |||||
| Gene ID | 23415 | |||||
| Synonyms |
Potassium voltage-gated channel subfamily H member 4; Brain-specific eag-like channel 2; BEC2; Ether-a-go-go-like potassium channel 1; ELK channel 1; ELK1; Voltage-gated potassium channel subunit Kv12.3
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| 3D Structure | ||||||
| Sequence |
MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESA
GGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEG GLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHT DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVV VNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC |
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| Target Bioclass |
Transporter and channel
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| Family |
Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv12.3/KCNH4 sub-subfamily
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| Subcellular location |
Membrane
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| Function | Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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m-APA Probe Info |
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N.A. | LDD2231 | [1] | |