Details of the Target

General Information of Target

Target ID LDTP13740
Target Name Coronin-2B (CORO2B)
Gene Name CORO2B
Gene ID 10391
Synonyms
KIAA0925; Coronin-2B; Coronin-like protein C; Clipin-C; Protein FC96
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA
NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG
FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP
IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ
CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDS
EKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDH
PSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWAD
LDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPT
LRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNS
VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHT
QPRSTPGLIPRPPAAQPVHGRTDWASKYASRR
Target Bioclass
Other
Family
WD repeat coronin family
Subcellular location
Cytoplasm, cytoskeleton
Function May play a role in the reorganization of neuronal actin structure.
Uniprot ID
Q9UQ03
Ensemble ID
ENST00000261861.10
HGNC ID
HGNC:2256

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.H44Y DBIA    Probe Info 
HCT15 SNV: p.S155G .
ICC4 SNV: p.C335F DBIA    Probe Info 
IGR1 Substitution: p.P69L DBIA    Probe Info 
IPC298 SNV: p.P276L DBIA    Probe Info 
NCIH358 SNV: p.L397F DBIA    Probe Info 
NCIN87 SNV: p.V419F .
RKO SNV: p.S137N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K416(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C335(1.62); C46(1.36); C220(1.46)  LDD3332  [2]
IPM
 Probe Info  		C30(3.24)  LDD1701  [3]
1d-yne
 Probe Info  		N.A.  LDD0357  [4]
W1
 Probe Info  		N.A.  LDD0236  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C335(1.25)  LDD2244  [2]
 LDCM0023  KB03 MDA-MB-231 C30(3.24)  LDD1701  [3]
 LDCM0024  KB05 MKN45 C335(1.62); C46(1.36); C220(1.46)  LDD3332  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid protein-binding protein 2 (APPBP2) . Q92624

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.