Details of the Target

General Information of Target

Target ID LDTP13729
Target Name Protein unc-13 homolog A (UNC13A)
Gene Name UNC13A
Gene ID 23025
Synonyms
KIAA1032; Protein unc-13 homolog A; Munc13-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGLMI
PVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKL
GRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALK
ELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERE
NLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSP
QLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEV
SPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQN
FLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGAN
INITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCT
IRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEA
PPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTII
KFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENA
DKSKAAPAEIDQR
Target Bioclass
Other
Family
Unc-13 family
Subcellular location
Cytoplasm
Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes.
Uniprot ID
Q9UPW8
Ensemble ID
ENST00000519716.7
HGNC ID
HGNC:23150

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C595(2.08); C603(2.08)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C890(1.50); C883(1.08)  LDD1508  [2]
 LDCM0277  AC18 HEK-293T C890(1.02); C883(0.98)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C890(1.24); C883(1.07)  LDD1518  [2]
 LDCM0286  AC26 HEK-293T C890(1.22); C883(0.99)  LDD1525  [2]
 LDCM0295  AC34 HEK-293T C890(0.91); C883(1.02)  LDD1534  [2]
 LDCM0304  AC42 HEK-293T C890(0.82); C883(0.94)  LDD1543  [2]
 LDCM0313  AC50 HEK-293T C890(0.97); C883(0.87)  LDD1552  [2]
 LDCM0321  AC58 HEK-293T C890(1.00); C883(0.89)  LDD1560  [2]
 LDCM0405  CL18 HEK-293T C890(0.93); C883(0.92)  LDD1609  [2]
 LDCM0419  CL30 HEK-293T C890(1.03); C883(0.92)  LDD1623  [2]
 LDCM0432  CL42 HEK-293T C890(0.91); C883(0.81)  LDD1636  [2]
 LDCM0445  CL54 HEK-293T C890(0.83); C883(0.84)  LDD1648  [2]
 LDCM0451  CL6 HEK-293T C890(0.73); C883(0.98)  LDD1654  [2]
 LDCM0458  CL66 HEK-293T C890(1.03); C883(0.83)  LDD1661  [2]
 LDCM0471  CL78 HEK-293T C890(0.90); C883(0.89)  LDD1674  [2]
 LDCM0485  CL90 HEK-293T C890(0.56); C883(1.09)  LDD1688  [2]
 LDCM0022  KB02 HCT 116 C595(2.08); C603(2.08)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C595(3.73); C603(3.73)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C595(2.76); C603(2.76)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402