Details of the Target

General Information of Target

Target ID LDTP13697
Target Name B9 domain-containing protein 1 (B9D1)
Gene Name B9D1
Gene ID 27077
Synonyms
MKSR1; B9 domain-containing protein 1; MKS1-related protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQEL
SSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAV
SLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHS
KEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGY
KDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLD
ESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKAL
TYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQS
KEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDD
ETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKL
LMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENV
ELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFE
PYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKE
SKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTI
NLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGD
KELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKES
SLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLE
IFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLE
FSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHI
IEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS
Target Bioclass
Other
Family
B9D family
Subcellular location
Cytoplasm, cytoskeleton, cilium basal body
Function
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
Uniprot ID
Q9UPM9
Ensemble ID
ENST00000261499.11
HGNC ID
HGNC:24123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(0.91)  LDD1576  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C33(0.91)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C33(1.14)  LDD1580  [1]
 LDCM0381  CL111 HEK-293T C33(0.94)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C33(1.07)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C33(1.15)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C33(1.01)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C33(1.05)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C33(0.89)  LDD1606  [1]
 LDCM0415  CL27 HEK-293T C33(1.00)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C33(1.03)  LDD1622  [1]
 LDCM0428  CL39 HEK-293T C33(0.82)  LDD1632  [1]
 LDCM0455  CL63 HEK-293T C33(1.27)  LDD1658  [1]
 LDCM0481  CL87 HEK-293T C33(0.88)  LDD1684  [1]
 LDCM0494  CL99 HEK-293T C33(0.96)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C33(0.93)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C33(1.02)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402