Details of the Target

General Information of Target

Target ID LDTP13686
Target Name Transferrin receptor protein 2 (TFR2)
Gene Name TFR2
Gene ID 7036
Synonyms
Transferrin receptor protein 2; TfR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLW
LLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPIS
IPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL
EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTP
SLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPC
EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSG
CYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWW
VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVG
LNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVF
SVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDF
TVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
Target Bioclass
Transporter and channel
Family
Peptidase M28 family, M28B subfamily
Subcellular location
Cytoplasm; Cell membrane
Function Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Uniprot ID
Q9UP52
Ensemble ID
ENST00000223051.8
HGNC ID
HGNC:11762
ChEMBL ID
CHEMBL3988361

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB2 SNV: p.Q20H .
HEC1 SNV: p.E769D .
IGR1 SNV: p.E37K .
KP4 SNV: p.P467A .
MOLT4 SNV: p.A77V .
RL SNV: p.S694I .
SKMEL2 SNV: p.P539L .
SNGM SNV: p.H739R .
SNU1 SNV: p.V277A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C416(1.68)  LDD2302  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C416(1.68)  LDD2302  [2]
 LDCM0023  KB03 CMK C416(1.87)  LDD2719  [2]
 LDCM0024  KB05 CMK C416(1.87)  LDD3136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Olfactomedin-4 (OLFM4) . Q6UX06

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ferric Derisomaltose . DB15617
Ferrous Sulfate Anhydrous . DB13257

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840