Details of the Target

General Information of Target

Target ID LDTP13670
Target Name Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)
Gene Name ST3GAL5
Gene ID 8869
Synonyms
SIAT9; Lactosylceramide alpha-2,3-sialyltransferase; EC 2.4.3.9; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEG
PDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCEL
PPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELRE
FLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Glycosyltransferase 29 family
Subcellular location
Golgi apparatus membrane
Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer).
TTD ID
T37271
Uniprot ID
Q9UNP4
DrugMap ID
TTVF2BJ
Ensemble ID
ENST00000393805.6
HGNC ID
HGNC:10872

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.T3M .
HCT15 SNV: p.P311L .
Ishikawa (Heraklio) 02 ER SNV: p.P45S; p.V269D .
JURKAT SNV: p.Q48Ter .
LS180 Insertion: p.M97NfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C8(3.74)  LDD3332  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C8(2.59)  LDD2250  [1]
 LDCM0023  KB03 A101D C8(3.26)  LDD2667  [1]
 LDCM0024  KB05 MKN45 C8(3.74)  LDD3332  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Carbocisteine Small molecular drug DB04339
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5'-deoxy-5'-[(3-hydrazinopropyl)Methylamino]Adenosine Small molecular drug D0V2QF
99mtc-14 F7 Mab . DB05867

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840