Details of the Target

General Information of Target

Target ID LDTP13659
Target Name Dual specificity protein phosphatase CDC14A (CDC14A)
Gene Name CDC14A
Gene ID 8556
Synonyms
Dual specificity protein phosphatase CDC14A; EC 3.1.3.16; EC 3.1.3.48; CDC14 cell division cycle 14 homolog A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMA
KFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKN
KDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
Subcellular location
Nucleus
Function
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Uniprot ID
Q9UNH5
Ensemble ID
ENST00000336454.5
HGNC ID
HGNC:1718
ChEMBL ID
CHEMBL1772926

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.A482T .
HCT15 SNV: p.L572P .
JURKAT SNV: p.Q320Ter .
LS123 SNV: p.A482T .
MDST8 SNV: p.R345Ter .
OVISE SNV: p.R473G .
REH SNV: p.A275T .
TYKNU SNV: p.A103T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K79(8.12)  LDD0275  [1]
DBIA
 Probe Info  		C12(0.91)  LDD1492  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C12(0.91)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C12(0.99)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C12(1.09)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019