Details of the Target

General Information of Target

Target ID LDTP13632
Target Name Membrane-associated transporter protein (SLC45A2)
Gene Name SLC45A2
Gene ID 51151
Synonyms
AIM1; MATP; Membrane-associated transporter protein; Melanoma antigen AIM1; Protein AIM-1; Solute carrier family 45 member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEG
MFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEG
IYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKML
QMDMNPSSWLAQQRRKSAMF
Target Bioclass
Transporter and channel
Family
Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
Subcellular location
Melanosome membrane
Function
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR.
Uniprot ID
Q9UMX9
Ensemble ID
ENST00000296589.9
HGNC ID
HGNC:16472

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.V111F .
HCT15 SNV: p.S39G .
HT115 SNV: p.K289N .
HUH7 Insertion: p.V144KfsTer11 .
IGR1 SNV: p.T108I; p.P315S DBIA    Probe Info 
MCC13 SNV: p.G269S .
NCIH1792 SNV: p.G396E .
TE10 SNV: p.E26Ter .
TYKNU SNV: p.A124D .
U937 SNV: p.S90Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C171(2.58)  LDD3413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C171(1.37)  LDD2253  [1]
 LDCM0023  KB03 A2058 C171(1.92)  LDD2670  [1]
 LDCM0024  KB05 RVH-421 C171(2.58)  LDD3413  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840