Details of the Target

General Information of Target

Target ID LDTP13613
Target Name Collagen alpha-1(XVII) chain (COL17A1)
Gene Name COL17A1
Gene ID 1308
Synonyms
BP180; BPAG2; Collagen alpha-1(XVII) chain; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-1; 97 kDa linear IgA disease antigen; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa; LABD97)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKPSSMDTKFKDDLFRKYVQFHESKVDTTTSRQRPGSDECLRVAASTLLSLHKVDPFYR
FRLIQFYEVVESSLRSLSSSSLRALHGAFSMLETVGINLFLYPWKKEFRSIKTYTGPFVY
YVKSTLLEEDIRAILSCMGYTPELGTAYKLRELVETLQVKMVSFELFLAKVECEQMLEIH
SQVKDKGYSELDIVSERKSSAEDVRGCSDALRRRAEGREHLTASMSRVALQKSASERAAK
DYYKPRVTKPSRSVDAYDSYWESRKPPLKASLSLRKEPVATDVGDDLKDEIIRPSPSLLT
MASSPHGSPDVLPPASPSNGPALLRGTYFSTQDDVDLYTDSEPRATYRRQDALRPDVWLL
RNDAHSLYHKRSPPAKESALSKCQSCGLSCSSSLCQRCDSLLTCPPASKPSAFPSKASTH
DSLAHGASLREKYPGQTQGLDRLPHLHSKSKPSTTPTSRCGFCNRPGATNTCTQCSKVSC
DACLSAYHYDPCYKKSELHKFMPNNQLNYKSTQLSHLVYR
Target Bioclass
Other
Subcellular location
Cell junction, hemidesmosome; Secreted, extracellular space, extracellular matrix, basement membrane
Function
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Uniprot ID
Q9UMD9
Ensemble ID
ENST00000369733.8
HGNC ID
HGNC:2194

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.K466R .
CCK81 SNV: p.P119L .
COLO320 SNV: p.E53G .
COLO679 SNV: p.G894R .
HCT116 SNV: p.S986T .
HEC1 SNV: p.G906A .
IGR1 SNV: p.P260S .
KMCH1 SNV: p.P91S .
LNCaP clone FGC SNV: p.A376V .
MCC13 SNV: p.S29F; p.S218F .
MEWO SNV: p.G824R .
MFE319 SNV: p.V259F .
NCIH146 SNV: p.G827E .
NCIH1792 SNV: p.S243T .
NCIH23 SNV: p.P1269H .
NCIH446 SNV: p.G1005C .
SAOS2 SNV: p.L225V .
SKMEL3 SNV: p.G39V .
SNU1196 SNV: p.G297D .
SNU423 SNV: p.G767C .
SW1271 SNV: p.P569R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C328(1.77)  LDD2370  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HT-1376 C328(1.77)  LDD2370  [1]
 LDCM0023  KB03 HT-1376 C328(2.16)  LDD2787  [1]
 LDCM0024  KB05 J82 C328(1.49)  LDD3236  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840