Details of the Target

General Information of Target

Target ID LDTP13598
Target Name Matrix metalloproteinase-17 (MMP17)
Gene Name MMP17
Gene ID 4326
Synonyms
MT4MMP; Matrix metalloproteinase-17; MMP-17; EC 3.4.24.-; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
LRESQSYLVEDLERS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M10A family
Subcellular location
Cell membrane
Function
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
TTD ID
T55616
Uniprot ID
Q9ULZ9
DrugMap ID
TTVSZKN
Ensemble ID
ENST00000360564.5
HGNC ID
HGNC:7163
ChEMBL ID
CHEMBL2937

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 Insertion: p.S531RfsTer22 .
AGS SNV: p.C523G .
EGI1 SNV: p.W406L .
HCT15 SNV: p.A244V .
IM95 SNV: p.R45H .
Ishikawa (Heraklio) 02 ER SNV: p.Q496H .
JURKAT SNV: p.S320Y .
MCC13 SNV: p.P283L .
MCC26 Substitution: p.P323L .
NCIH358 SNV: p.L49F .
P31FUJ SNV: p.A338S .
SW403 SNV: p.P42H .
TE4 SNV: p.R473S .
TOV21G SNV: p.L312V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264