Details of the Target

General Information of Target

Target ID LDTP13590
Target Name RING finger protein 112 (RNF112)
Gene Name RNF112
Gene ID 7732
Synonyms
BFP; ZNF179; RING finger protein 112; EC 2.3.2.27; Brain finger protein; Zinc finger protein 179
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLP
EYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPE
TPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGE
DVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFA
MQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTV
SDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTN
VFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily
Subcellular location
Membrane
Function
E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density.
Uniprot ID
Q9ULX5
Ensemble ID
ENST00000461366.2
HGNC ID
HGNC:12968

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.D71N .
HCC70 SNV: p.V565M .
LN18 SNV: p.V300A .
MFE319 SNV: p.Y388C .
MOLT4 SNV: p.R141H .
NCIH1993 SNV: p.R365L .
OPM2 SNV: p.R481C .
T24 SNV: p.E177K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C12(1.48)  LDD3339  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 JeKo-1 C12(1.40)  LDD2403  [1]
 LDCM0023  KB03 JeKo-1 C12(1.48)  LDD2820  [1]
 LDCM0024  KB05 NALM-6 C12(1.48)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840