Details of the Target

General Information of Target

Target ID LDTP13587
Target Name Nucleosome assembly protein 1-like 2 (NAP1L2)
Gene Name NAP1L2
Gene ID 4674
Synonyms
BPX; Nucleosome assembly protein 1-like 2; Brain-specific protein, X-linked
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRKKTPKSKGASTPAASTLPTANGARPARSGTALSGPDAPPNGPLQPGRPSLGGGVDFY
DVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGVKVKLQMWDT
AGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEIHEYAQHDVALMLLGNKVD
SAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELKQRSMKAPSEPRFRL
HDYVKREGRGASCCRP
Target Bioclass
Other
Family
Nucleosome assembly protein (NAP) family
Subcellular location
Nucleus
Function Acidic protein which may be involved in interactions with other proteins or DNA.
Uniprot ID
Q9ULW6
Ensemble ID
ENST00000373517.4
HGNC ID
HGNC:7638

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 Deletion: p.D223del .
DU145 Substitution: p.G191F .
HCT15 SNV: p.V405A .
HUCCT1 SNV: p.N372K .
ICC4 SNV: p.A114S .
MCC13 SNV: p.P146L .
NCIH1666 SNV: p.V405L .
RKO SNV: p.E160G .
RL952 SNV: p.G48S .
TE4 SNV: p.E3D .
WM2664 Insertion: p.K367QfsTer22 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		N.A.  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010