Details of the Target

General Information of Target

Target ID LDTP13586
Target Name Ras-related protein Rab-26 (RAB26)
Gene Name RAB26
Gene ID 25837
Synonyms
Ras-related protein Rab-26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAEESEKAATEQEPLEGTEQTLDAEEEQEESEEAACGSKKRVVPGIVYLGHIPPRFRPL
HVRNLLSAYGEVGRVFFQAEDRFVRRKKKAAAAAGGKKRSYTKDYTEGWVEFRDKRIAKR
VAASLHNTPMGARRRSPFRYDLWNLKYLHRFTWSHLSEHLAFERQVRRQRLRAEVAQAKR
ETDFYLQSVERGQRFLAADGDPARPDGSWTFAQRPTEQELRARKAARPGGRERARLATAQ
DKARSNKGLLARIFGAPPPSESMEGPSLVRDS
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Golgi apparatus membrane
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.
Uniprot ID
Q9ULW5
Ensemble ID
ENST00000210187.11
HGNC ID
HGNC:14259

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
K562 SNV: p.G110S .
SW620 SNV: p.P42T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C78(1.67)  LDD2265  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C78(1.67)  LDD2265  [1]
 LDCM0023  KB03 AU565 C78(2.40)  LDD2682  [1]
 LDCM0024  KB05 AU565 C78(2.36)  LDD3099  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2B adrenergic receptor (ADRA2B) G-protein coupled receptor 1 family P18089
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Protein Mis18-beta (OIP5) Mis18 family O43482
Four and a half LIM domains protein 5 (FHL5) . Q5TD97

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255