Details of the Target
General Information of Target
| Target ID | LDTP13576 | |||||
|---|---|---|---|---|---|---|
| Target Name | Calcium-dependent secretion activator 1 (CADPS) | |||||
| Gene Name | CADPS | |||||
| Gene ID | 8618 | |||||
| Synonyms |
CAPS; CAPS1; KIAA1121; Calcium-dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; CAPS-1 |
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| 3D Structure | ||||||
| Sequence |
MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE
LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD |
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| Target Bioclass |
Other
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| Subcellular location |
Synapse
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| Function |
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| BT549 | SNV: p.S34P | . | |||
| EFO27 | SNV: p.E16K | . | |||
| HCC1954 | SNV: p.D1231G | . | |||
| HCT116 | Deletion: p.L78CfsTer20 | . | |||
| HEPG2 | SNV: p.L281P | . | |||
| HKGZCC | SNV: p.L847Ter | . | |||
| HT1197 | SNV: p.P828Q | . | |||
| IGR37 | SNV: p.G769E | DBIA Probe Info | |||
| IGR39 | SNV: p.G769E | . | |||
| IM95 | Deletion: p.L78CfsTer20 | . | |||
| JHH7 | SNV: p.A866E | . | |||
| JURKAT | SNV: p.Y1199C | . | |||
| KO52 | SNV: p.E781Ter | . | |||
| KPNYN | SNV: p.K1184N | . | |||
| LS123 | Substitution: p.S93T | DBIA Probe Info | |||
| MCC13 | SNV: p.E598K | . | |||
| MCC26 | SNV: p.P1084L | . | |||
| MEWO | SNV: p.G166R; p.G599R | . | |||
| MFE319 | SNV: p.D986Y | . | |||
| NCIH1666 | SNV: p.A43P | . | |||
| NCIH2170 | SNV: p.L164H; p.K361N | . | |||
| NCIH2172 | SNV: p.P830T | . | |||
| OVKATE | SNV: p.D1344N | . | |||
| SBC5 | SNV: p.Q435H | . | |||
| SNGM | SNV: p.S1264N | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C421(3.23); C1275(1.09) | LDD3344 | [1] | |
|
IA-alkyne Probe Info |
 |
C128(1.92) | LDD2188 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0573 | Fragment11 | Ramos | C128(0.30) | LDD2190 | [2] |
| LDCM0574 | Fragment12 | Ramos | C128(0.65) | LDD2191 | [2] |
| LDCM0576 | Fragment14 | Ramos | C128(1.11) | LDD2193 | [2] |
| LDCM0571 | Fragment9 | Ramos | C128(1.92) | LDD2188 | [2] |
| LDCM0022 | KB02 | CCK-81 | C729(3.76); C202(3.52) | LDD2297 | [1] |
| LDCM0023 | KB03 | CCK-81 | C729(6.12); C202(8.90) | LDD2714 | [1] |
| LDCM0024 | KB05 | NCI-H146 | C421(3.23); C1275(1.09) | LDD3344 | [1] |
References