Details of the Target

General Information of Target

Target ID LDTP13566
Target Name Protein NDRG4 (NDRG4)
Gene Name NDRG4
Gene ID 65009
Synonyms
BDM1; KIAA1180; Protein NDRG4; Brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; Vascular smooth muscle cell-associated protein 8; SMAP-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD
NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF
QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP
DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE
VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV
EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA
HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG
VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT
NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL
LLPFLPQVNGIHLPGRR
Target Bioclass
Enzyme
Family
NDRG family
Subcellular location
Cytoplasm, cytosol
Function
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
Uniprot ID
Q9ULP0
Ensemble ID
ENST00000258187.9
HGNC ID
HGNC:14466

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AOyne
 Probe Info  		15.00  LDD0443  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) UbiG/COQ3 family Q9NZJ6
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Sphingomyelin phosphodiesterase 2 (SMPD2) Neutral sphingomyelinase family O60906
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Serine/threonine-protein kinase Sgk1 (SGK1) AGC Ser/Thr protein kinase family O00141
Epidermal retinol dehydrogenase 2 (SDR16C5) Short-chain dehydrogenases/reductases (SDR) family Q8N3Y7
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium channel flower homolog (CACFD1) Calcium channel flower family Q9UGQ2
Derlin-3 (DERL3) Derlin family Q96Q80
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Leucine-rich repeat-containing protein 59 (LRRC59) . Q96AG4
Proteolipid protein 2 (PLP2) . Q04941
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Complexin-2 (CPLX2) Complexin/synaphin family Q6PUV4
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Protein MAL2 (MAL2) MAL family Q969L2
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Protein YIF1A (YIF1A) YIF1 family O95070
Arfaptin-2 (ARFIP2) . P53365
Cerebellar degeneration-related antigen 1 (CDR1) . P51861
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.