Details of the Target

General Information of Target

Target ID LDTP13558
Target Name Glutamate receptor ionotropic, delta-1 (GRID1)
Gene Name GRID1
Gene ID 2894
Synonyms
KIAA1220; Glutamate receptor ionotropic, delta-1; GluD1; GluR delta-1 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG
SNVNRIKNLFMQMGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSV
SERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKS
NRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPS
VTVTNLDTFGHLKDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQS
KEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQ
RKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTE
QDEEEDSDENSYYQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRND
EVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVT
EGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVA
QLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELP
ENEDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQ
NIEENKERMLKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELD
FIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRTS
LGEVSKGDTMENLDGKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPSR
TRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDES
LDMIDDEILDDGQSPKHSQCQNRAVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLL
QLDGNKLKALGMTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRK
SKKTEKMTSTTAEGAGEQ
Target Bioclass
Transporter and channel
Family
Glutamate-gated ion channel (TC 1.A.10.1) family, GRID1 subfamily
Subcellular location
Cell membrane
Function
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Uniprot ID
Q9ULK0
Ensemble ID
ENST00000327946.12
HGNC ID
HGNC:4575
ChEMBL ID
CHEMBL4524129

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.S186W .
CCK81 SNV: p.A744V .
COLO792 SNV: p.N651H .
DU145 Substitution: p.R692I .
EFO27 SNV: p.F976L .
HCC15 SNV: p.N872K .
HCC827 SNV: p.L851V .
JHH7 SNV: p.L313F .
KYSE180 SNV: p.D662E .
KYSE30 SNV: p.V758M .
LS180 SNV: p.G465W .
MEWO SNV: p.S302F .
MFE296 SNV: p.R125H .
MFE319 SNV: p.L321I .
MOLT4 SNV: p.M109I; p.S180N .
NCIH2172 SNV: p.E395K; p.S944Ter .
SH4 SNV: p.L231F .
UMUC3 SNV: p.R512K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019