Details of the Target

General Information of Target

Target ID LDTP13526
Target Name Myelin transcription factor 1-like protein (MYT1L)
Gene Name MYT1L
Gene ID 23040
Synonyms
KIAA1106; Myelin transcription factor 1-like protein; MyT1-L; MyT1L
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLIL
KLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHK
IDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLC
LKHFRQHNYTEAFESLQKKTKIALEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQ
YISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADF
WAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSD
FYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRA
SEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKT
YLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKR
EENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYL
FGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQVDPLSALKYLQ
NDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPD
SMTPPKGNLVDLITL
Target Bioclass
Transcription factor
Family
MYT1 family
Subcellular location
Nucleus
Function
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
Uniprot ID
Q9UL68
Ensemble ID
ENST00000399161.8
HGNC ID
HGNC:7623

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.Q780P; p.G988R .
COLO792 SNV: p.D1013N .
DU4475 SNV: p.A711T .
HCT116 SNV: p.G309R .
HCT15 SNV: p.T655A .
HEC1B SNV: p.P553L .
HGC27 SNV: p.R444K .
HL60 SNV: p.Y110D .
HT115 SNV: p.A542V; p.A728V .
IGROV1 Deletion: p.G708AfsTer43 .
JURKAT SNV: p.T861I .
KNS81FD SNV: p.D495Y .
KYSE410 SNV: p.S420C .
LS180 SNV: p.D602A .
MCC13 SNV: p.D336N; p.E466K .
MDAMB453 SNV: p.M173I .
MDST8 SNV: p.E466K .
MEWO SNV: p.F78V; p.E162K; p.W997Ter .
MM1S SNV: p.S891I .
NCIH1155 SNV: p.R349M .
NCIH146 SNV: p.A981E .
NCIH1993 SNV: p.R938M .
NCIH358 SNV: p.L208F .
NCIH446 SNV: p.S1019R .
OCUM1 SNV: p.D4N .
PC14 SNV: p.A970V .
PC9 SNV: p.A970V .
SKMEL2 SNV: p.A72D .
SW1271 SNV: p.E647V .
ZR751 SNV: p.R924W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C929(1.30)  LDD3340  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DU145 C574(1.31)  LDD2318  [1]
 LDCM0023  KB03 DU145 C574(1.17)  LDD2735  [1]
 LDCM0024  KB05 NB1 C929(1.30)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060